After playing Natalie Sanford in the independent film The Secret Life of Girls, Delfino was cast as Maria DeLuca on Roswell.

Delfino starred in several episodes of the NBC show Quarterlife, also shown on MySpaceTV, which started airing November 11, 2007.

Delfino performed in ABC's pilot The Family Trap starring Mandy Moore and Stockard Channing.

She was eight months pregnant with her first child during the shooting, so director Shawn Levy shot around the pregnancy for the entire project.

In the summer of 2000, she released three songs onto the internet, "Siren", "Bruises" and "Tattoo", written and produced in association with "Sci-Fi Lullaby."