"Make Me Wanna Scream" is the second and final single from American R&B singer Blu Cantrell's second studio album, Bittersweet (2003).

The song features Ian Lewis from Jamaican reggae band Inner Circle.

It features Cantrell walking through a city with her friends in the background and of her driving a Mercedes.

The ex-boyfriend, who comes out of his house at the end of the video and notices the girls painting "pig" on his car, was believed to be Simon Webbe (from the English boy band Blue), but it was actually her then-boyfriend Tony De Nero.

Although failing to match the success of previous single "Breathe", "Make Me Wanna Scream" still managed to chart moderately in the United Kingdom, Germany, Austria, Switzerland, Ireland, and Australia.