[4] Toward the end of the 6th century, a scion of the Makhzum, Hisham ibn al-Mughira, grew to such prominence in Mecca that the Quraysh established a dating system that began with his death.
[6] One of their chieftains, Abu Jahl, led Meccan opposition to the Muslims and organized a boycott of Muhammad's clan, the Banu Hashim, in circa 616–618.
[6] The casualties the Makhzum sustained led to a significant weakening of their position in Mecca and they were passed in prominence by the Banu Abd Shams under the leadership of Abu Sufyan.
At least three members of the Makhzum, all from cadet branches, fought alongside Muhammad at Badr, and by the time he launched his conquest of Mecca in January 630, several others had defected to him, including one of their eminent military commanders, Khalid ibn al-Walid, a grandson of al-Mughira.
[6] The most prominent role by a member of the Makhzum during this period was played by Khalid who scored key victories against Musaylima in the Yamama during the Ridda wars and against the Byzantines during the Muslim conquest of Syria (634–638).