The same year, Stanley Kramer signed Powers to star with José Ferrer in what may be her most-remembered role as Roxane in Cyrano de Bergerac.

[citation needed] Following her recovery, she appeared in Bengazi (1955) and B-movies such as Rage at Dawn (1955), The Storm Rider (1957), and Sierra Baron (1958), and science-fiction films, including The Unknown Terror (1957), The Colossus of New York (1958), Flight of the Lost Balloon (1961), and Doomsday Machine (1972).

She appeared in more than 100 TV episodes, including Appointment with Adventure, Crossroads, Mr. Adams and Eve, The Restless Gun, Wagon Train, Bourbon Street Beat, The Rebel, Maverick (in an episode called "Dutchman's Gold" with Roger Moore), The Everglades, Bonanza, The Man from U.N.C.L.E.

(The Virtue Affair), Mission: Impossible, Bewitched, The Wild Wild West, The Silent Force, Cheyenne (episodes "Alibi for the Scalped Man" (1960) and "Trouble Street" (1961)), and the Wanted: Dead or Alive episode "Till Death do us Part", with Steve McQueen.

Her most memorable role was as defendant Janet Brent, friend of Perry's secretary Della Street (Barbara Hale), in the 1962 episode "The Case of the Weary Watchdog".

[7] Powers trained directly under Michael Chekhov for many years during her time in Hollywood in both group and private sessions.

She also published Chekhov's audio series "On Theatre and the Art of Acting", to which she added a 60-page study guide.

She co-narrated with Gregory Peck a documentary on Chekhov titled From Russia to Hollywood, which was co-produced by her colleague Lisa Loving.

[12] Powers died from complications of leukemia on June 11, 2007, at Providence Saint Joseph Medical Center in Burbank, California.

[2] She was cremated at the Hollywood Hills Forest Lawn Memorial Park and her ashes returned to family.