In enzymology, a malate dehydrogenase (NADP+) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are (S)-malate and NADP+, whereas its 3 products are oxaloacetate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase.

This enzyme participates in pyruvate metabolism and carbon fixation.

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CIV and 7MDH.