Malatesta IV Baglioni (1491 – 24 December 1531) was an Italian condottiero and lord of Perugia, count of Bettona and Spello, and other lands in Umbria.

He was the son of Gian Paolo Baglioni, ruler of Perugia, and Ippolita Conti.

During the War of the League of Cognac, Malatesta left Perugia to Philibert of Orange, chief of the Imperial army in Italy, to assume the defence of the Republic of Florence.

A secret agreement with Pope Clement VII and the Imperials stated that he would receive the city back after his condotta for Florence ended.

His treason was revealed on 3 August 1530, at the Battle of Gavinana, in which the Florentine force under Francesco Ferrucci was destroyed by the Imperial army.