The United States has an active Peace Corps program, Centers for Disease Control and Prevention, Department of Health and Human Services, and an Agency for International Development (USAID) mission in Malawi.

Through a pragmatic assessment of its own national interests and foreign policy objectives, Malawi advocates peaceful solutions to the region's problems through negotiation.

USAID's program to increase rural incomes includes training and technical assistance to increase smallholder (crop, dairy, forest, and fishery) productivity; foster additional trade linkages among small farmer producer associations, larger commodity-specific industry clusters, and export markets (e.g. cassava, chilies, groundnuts, cotton, coffee, etc.

The Democracy and Governance portfolio continued to evolve in 2007, which proved to be an important transition year for the MCC Threshold Country Program (TCP).

Activities under the TCP reaped positive results in fighting corruption, improving fiscal responsibility, and establishing a more transparent and effective judiciary.

Partly as a result of successes gained under the TCP, the Government of Malawi was the only country in the world selected by MCC in December 2007 for Compact eligibility.

Several other Democracy and Governance activities continued to fight corruption in the private sector, educate at-risk youth of their civic responsibilities, and nurture Christian/Muslim dialogue and relationships.

In addition, according to a national Demographic and Health Survey (DHS) completed in 2005 with support from USAID, USAID's Presidential Emergency Plan for HIV/AIDS Relief activities reached 1,351,404 people through ABC messages (abstinence from sexual activity, being faithful to a single partner, and correct and consistent condom use) and provided care to 57,356 HIV/AIDS orphans and vulnerable children.

Under-five mortality rates declined from a high of 189 per thousand live births in 2000 to 133 per thousand live births in 2004; the total fertility rate (TFR) declined to 6 children per woman, and the proportion of Malawian children sleeping under an insecticide-treated bed nets (ITN) (26% in 2004) was more than three times the proportion (8%) sleeping under an ITN in 2000.

Key achievements in 2007 under the Presidential Malaria Initiative (PMI) included: the distribution of 185,400 long-lasting insecticide-treated mosquito nets and 2,607,480 doses of a new life-saving drug delivered nationwide.

At the local level, USAID-funded activities are helping communities and parents make more informed decisions to improve the quality of primary schooling.

The CDC GAP office started in November 2001 with an emphasis on establishing long-term working relationships with the Malawi Government, the National AIDS Commission (NAC), and the Ministry of Health (MOH).

The major areas of focus during the initial phase included strengthening Voluntary counseling and testing (VCT), HIV surveillance, evaluation, infrastructure, and capacity-building activities.

BIMI was established in Blantyre District, Malawi in 1998 to promote sustainable and effective strategies to manage and prevent malaria-related morbidity and mortality.

Education volunteers teach in the fields of physical science, mathematics, biology, and English at Community Day Secondary Schools (CDSSs), generally community-started and -supported entities.

Crisis Corps volunteers are generally assigned with a local NGO to assist with activities that build capacity and develop materials within the organizations.