In 2014–15, he was named as a consensus second-team All-American, as well as the first-team All-ACC and ACC Co-Defensive Player of the Year.

[6] He made his NBA debut in the Bucks' season opener on October 26, 2016, recording eight points and five assists in 21 minutes in a 107–96 loss to the Charlotte Hornets.

[21] On February 2, 2018, he was ruled out for six to eight weeks after suffering a partially torn left quadriceps tendon the previous night against the Minnesota Timberwolves.

[23] On November 28, 2018, Brogdon scored 24 points in 29 minutes on 6-for-6 three-point field goal shooting in a 116–113 win against the Chicago Bulls.

[30] On June 29, 2019, the Bucks extended a qualifying offer to Brogdon in order to make him a restricted free agent.

[31] On July 6, 2019, Brogdon signed with the Indiana Pacers via a sign-and-trade with the Milwaukee Bucks in exchange for future picks.

[33] New to starting at the point guard position, Brogdon studied tape of former NBA All-Star Isiah Thomas in the off-season.

[40] On January 4, Brogdon put up 21 points, 11 assists, seven rebounds, three steals, and one block, alongside a game-winning layup, in a 118–116 overtime win over the New Orleans Pelicans.

[48] On July 9, 2022, Brogdon was traded to the Boston Celtics in exchange for Aaron Nesmith, Daniel Theis, Nik Stauskas, Malik Fitts, Juwan Morgan, and a 2023 first-round draft pick.

[53] During the Eastern Conference Finals versus the Miami Heat, Brogdon played through an arm injury that was later revealed to be a partial tear of a tendon in his right elbow.

[54] On June 21, it was reported that Brogdon would be sent to the Los Angeles Clippers in a three-team trade involving the Washington Wizards.

However, reports later that day stated that the trade had fallen through, largely due to the Clippers raising concerns about Brogdon's injury status.

[56] On October 1, 2023, Brogdon, along with Robert Williams III and two future first-round draft picks, was traded to the Portland Trail Blazers in exchange for Jrue Holiday.

[59] Brogdon represented the United States national team[60] at the 2015 Pan American Games,[61] where he won a bronze medal.

[65] In 2018, Brogdon partnered with The Chris Long Foundation on their Hoops2O initiative, a program aimed at addressing the clean-water crisis, particularly in Africa.

[68] Brogdon is a member of the "Starting Five", along with Joe Harris, Justin Anderson, Anthony Tolliver, and Garrett Temple, who initially made a goal to raise $225,000 through Hoops2O to fund five wells in East Africa by the end of the 2018–19 season.

[69] Brogdon traveled with Anderson and Harris to Tanzania to witness the opening of the first well they funded in July 2019, and by November Hoops2O had raised nearly $400,000.

[70][71] By February 2020, the program had funded the construction of ten wells in Tanzania and Kenya, bringing water to over 52,000 citizens.