Malignant pilomatricoma is a cutaneous condition characterized by a locally aggressive tumor composed of hair-matrix cells.

[2]: 671 [3] Malignant pilomatricoma usually manifests as a single firm, painless, movable, asymptomatic dermal or subcutaneous lump.

It has been shown that the underlying skin can become ulcerated and exhibit severe discoloration; the latter is thought to be one of the few significant indicators of cancer.

[6][8][12] The diagnosis is strongly supported by ulceration and infiltration into adnexal structures; some reports even establish a correlation between these findings and the degree of malignancy.

[14] The initial treatment strategy and the diagnosis of the suspicious lesion are the primary factors influencing the overall outcome in malignant pilomatricoma.