Rose played 13 seasons in the National Basketball Association (NBA), winning championships with the San Antonio Spurs in 1999 and 2003.

He was signed as a free agent by the San Antonio Spurs in 1997, and quickly became one of their more popular players due to his displays of hustle, defense, and skill despite being undersized.

On February 24, 2005, Rose was traded along with a pair of first-round draft picks to the New York Knicks for Nazr Mohammed and Jamison Brewer, much to the dismay of Spurs fans.

With star front court players Tim Duncan and David Robinson out, Rose stepped in as a starter.

He was also named the color analyst for the NBA Development League team, the Austin Toros, who broadcast their games on television for the first time.

Rose would be named Head of Basketball Operations for the NBA G-League on January 5, 2022 [11] Outside of basketball, Rose has been involved in the San Antonio community with his charity work and the San Antonio staple 'Malik's Philly's Phamous' restaurant, specializing in Philadelphia's beloved cheesesteak sandwiches & specialty fries.