Máel Ísu or Malise II (Modern Gaelic: Maol Íosa; died 1271) is the fifth known mormaer, or earl, of the Scottish region of Strathearn.
Malise first appears on record in 1244, when he promised to observe the Treaty of York, the signing of which had been witnessed by his father.
He was a friend of King Henry III of England, and was tasked by him to attend his daughter Margaret, when she became Queen of Scots as the wife of Alexander.
Throughout his life he made considerable gifts to Inchaffray Abbey, giving the monks command of several of his serfs, and the right to take stone from the quarry of Nethergask, as well as donating several monetary sums.
In addition, Sir Robert Sibbald once mentioned that in the late 17th century, there was a picture in the church which represented the Countess of Strathearn and her children kneeling for a blessing to St. Blane, though its whereabouts today are unknown.