The center is contained within the Temple–Tifereth Israel synagogue building, located at Silver Park, on the border between the suburbs of Hough and University Circle.

[3] The sanctuary contains three notable stained glass windows by Arthur Szyk that depict Gideon, Samson and Judah Maccabee.

The congregation now known as The Temple - Tifereth Israel owns the 1924 building, used on the High Holy Days as well as for life cycle events and meetings.

[7][8] The multi-phased project, carried out by architectural firm DLR Group, allowed the sanctuary to accommodate music performances, lectures, as well as a place of worship and expanded the facility for the university’s theater and dance departments.

Other locations include the Temple-Tifereth Israel Gallery at the Maltz Museum of Jewish Heritage and Temple Tifereth-Israel in Beachwood.