Mambray Creek is a locality in the Australian state of South Australia located on the east coast of the Spencer Gulf about 240 kilometres (150 mi) north of the state capital of Adelaide and about 40 kilometres (25 mi) north of the city of Port Pirie.

Firstly, Rodney Cockburn, author of Nomenclature of South Australia, suggested that the name is a derivation of ‘Mamre’ which was the name of a house near Angaston built by a William Salter.

Secondly, Norman Tindale, the anthropologist, advised that a word ‘mambiri’ used by local aboriginals for the 'native cherry' (Exocarpos cupressiformis) is the “more likely derivation.” [1] The locality occupies land extending from the coastline with Spencer Gulf in the west to the western side of the Flinders Ranges in the east and a portion extending to the north on the east side of both the Augusta Highway and Adelaide-Port Augusta railway line.

[1][8] Land use within the locality is divided between agriculture and conservation with the latter being associated the coastline in the west, and land in the locality’s east having specific requirements for the protection of its landscape or being part of the protected area known as the Mount Remarkable National Park.

[8] Mambray Creek, a fresh stream, passes through the locality from its source in the Flinders Ranges in the east to its mouth at Spencer Gulf in the west.