She began her career at the national radio station Cadena SER as a journalist and presenter before moving into public television with Televisión Española in October 2004.
[5][9] The public state television broadcaster Televisión Española employed Mendizábal to be a presenter of the TVE1 political debate programme 59 segundos [es] in October 2004.
[10] Mendizábal co-hosted the two-hour avant-garde journalism magazine programme Sexto Sentido with Helena Resano and Cristina Villanueva for one season commencing in November 2006.
[11] She presented the 2008 LaSexta fictional documentary series Viva la República [es] in which a theorised Republican faction victory in the Spanish Civil War and its effects on Spain are discussed.
[12] Mendizábal moderated a programme on LaSexta following a debate between prime ministerial candidates José Luis Rodríguez Zapatero and Mariano Rajoy prior to the 2008 Spanish general election.
[19] Mendizábal was signed to present the Palo y astilla [es] programme in 2019 in which she interviews notable Spanish figures about their life and background to how they were able to achieve success.
[20][21] She, César Carballo, José María Gay de Liébana, Yayo Herrero and Ainara Zubillaga co-authored the book Adelante: Solo existe el futuro.