Dash Rip Rock, Dillon Fence, Frente!, Fu Manchu, Fun-Da-Mental, Jason & the Scorchers, Jocelyn Montgomery, Joe Henry, Juliana Hatfield, Kill Creek, Machines of Loving Grace, Mark Lizotte, My Friend Steve, Pure, Seven Mary Three, Squirrel Nut Zippers, The Hope Blister, The Melvins, The Sidewinders, Vanilla Trainwreck, and Victoria Williams.

[5][6] Another early signing, Blake Babies, led by Berklee School of Music students Juliana Hatfield and John Strohm, released “Earwig” and “Sunburn” with Mammoth before breaking up.

[19] The label’s early success across a spectrum of genres with acts like Blake Babies, Chainsaw Kittens, Dash Rip Rock, Dillon Fence, Juliana Hatfield, Joe Henry and Machines of Loving Grace attracted the attention of Atlantic Records.

Frente!’s cover of New Order’s “Bizarre Love Triangle” went Top 10 on Billboard Modern Rock Charts, and its record, Marvin The Album, shipped more than 750,000 copies worldwide.

Mammoth set a precedent for recognizing and promoting female, alternative voices with acts, such as The Black Girls, Blake Babies, Juliana Hatfield, Frente!, and Victoria Williams.

[13][20][21][22] When Chris Douridas was the director of music at KCRW, Mammoth teamed with the radio station to release Rare on Air, a four-part compilation series featuring artists such as Radiohead, Tori Amos, Lindsey Buckingham, Los Lobos, Beck, Nick Cave, John Cale, World Party, Philip Glass, The Cranberries, Jackson Browne, Fiona Apple, Ben Folds, James Taylor, Ani Difranco, Randy Newman, Jeff Buckley, Mazzy Starr, Patti Smith, Tom Waits, PJ Harvey and Lucinda Williams.

Its debut album, American Standard, sold 1.3 million copies aloft the single "Cumbersome", making Seven Mary Three the record label's first platinum seller.