Born in Tarifa, Province of Cádiz, Mané started playing professional football with lowly Real Balompédica Linense and CD Díter Zafra, being limited to just eight Segunda División B games with the latter team.

[2][3] The following season he moved clubs again, this time to UD Almería; he quickly became first-choice, being instrumental in the side's first-ever promotion to La Liga.

[4] Mané's Almería performances were much admired over the course of 2007–08, represented by him being named in Sky Sports pundit Guillem Balagué's team of the campaign[5] as the Andalusians overachieved and finished eighth.

[6][7] On 3 June 2009, after appearing in 105 competitive matches for Almería (he would eventually total 125 across two spells),[8] Mané signed a four-year contract with Getafe CF.

[11] On 3 July 2013, aged nearly 32, Mané moved abroad for the first time, agreeing to a two-year deal at Maccabi Tel Aviv FC.