[2] The daughter of wealthy and famous novelist Meg Swift, Mimi is a young woman who seems to have a perfect life.

Despite her mother's newspaper artist friend Jimmy Kilmartin warnings of Alan's scandalous past revolving around women, Mimi is determined to one day become Mrs. Wythe.

Mimi is crushed when she finds out that Alan is marrying heiress Elizabeth Kent, but swallows her pride to serve as the bridesmaid.

Jimmy tries to prevent her from breaking up a marriage, but Mimi is determined to convince Alan to divorce Elizabeth so they can marry.

[3] In July 1937, it was announced that Richard Thorpe would direct the film, with Myrna Loy, Rosalind Russell, Melvyn Douglas and Franchot Tone in the leading roles.

[3] By the time shooting started, Myrna Loy was mourning with the death of her friend and colleague Jean Harlow.

[4] Nevertheless, she recalled that she experienced production of Man-Proof as joyful because of her positive experience with co-stars Pidgeon and Rosalind Russell.