Manabe Akikatsu (間部 詮勝, 30 March 1804 – 28 November 1884) was the 7th daimyō of Sabae Domain in Echizen Province under the Tokugawa shogunate of Edo period Japan.

Akikatsu was born at the Sabae Domain's Edo residence as the fifth son of Manabe Akihiro.

In 1858, he was restored to the post of rōjū by the Tairō Ii Naosuke, and quickly was seen as Ii's right-hand man, taking a leading role in difficult situations, such as the Ansei Purge, the ratification of the Ansei Treaties, and the opposition to Hitotsubashi Yoshinobu from becoming shōgun.

In particular, his heavy-handed approach to forcing Emperor Kōmei to accept the ratification of the Harris Treaty and his suppression of pro-Sonnō jōi samurai in Kyoto drew the wrath of Yoshida Shōin in particular, who made many inflammatory speeches and writings urging Manabe's assassination.

His wife was a daughter of Matsudaira Yasutō of Hamada Domain, and his son and heir was Manabe Akizane.