[4] The station closed to passenger services on 4 May 1844,[5] when the line was extended to join the Manchester and Leeds Railway at Hunt's Bank.

William Fairbairn, in the quest to perfect fireproof mill flooring, had developed a parabolic 'T' section girder that could span such a distance.

The station itself comprised a slightly curved brick viaduct that terminated in the slope that led up from Water Street to Deansgate, alongside Liverpool Road.

Of course, at that time, goods traffic was considered the most important potential source of income, and for this, the terminus was well placed in the midst of the Castlefield canal and warehousing complex.

A brick structure was erected next to it, incorporating elaborate door and window surrounds, the whole being finished in stucco rendering, scored to imitate stonework.

The passengers proceeded upstairs to the waiting room, and licensed "outdoor porters" took charge of their luggage, being paid a set scale of fees.

The planning of railway stations was clearly not so advanced at this time as supporting pillars of the building prevented certain carriage doors from opening fully.

The station buildings were extended in 1831 by the construction of a simple two-road carriage shed on top of a range of rooms along Liverpool Road.

The station building and adjacent historic railway warehouses now form part of Museum of Science and Industry in Manchester which is located in the Castlefield Urban Heritage Park.

[12] In May 2014, Network Rail reached an agreement with MOSI, in which the museum was to receive an undisclosed sum in compensation, and the objection was dropped.

[13] In March 2015, Patrick McLoughlin, Secretary of State for Transport, announced that the Ordsall Chord project was to go ahead with an estimated completion date of 2017.

It was confirmed that the operational rail link into Liverpool Road station would be severed as a result of this project,[14] and later in 2015 the main line connection was removed.