It is on the same site as Manchester Royal Infirmary and St Mary's Hospital for Women and Children.

The hospital was founded in 1814 on the initiative of William James Wilson and opened in King Street the following year.

[1] The building was damaged by a large bomb in the German air raid on 23 December 1940.

[3] Services moved to a new building on the Royal Infirmary site accessible to patients in 2009 and officially opened by the Queen in 2012.

"[8] The hospital started a contract with EMS Healthcare in November 2015 to provide a mobile medical unit for up to 40 patients a day with wet age-related macular degeneration operating at Trafford General Hospital.