Since 2024, it has been represented by Labour's Afzal Khan, who was MP for Manchester Gorton from 2017 to 2024.

Under the 2023 periodic review of Westminster constituencies, the seat was re-established for the 2024 general election.

[2] The constituency was created as Manchester, Rusholme Division by the Representation of the People Act 1918, and was defined as consisting of three wards of the county borough of Manchester, namely Levenshulme, Longsight and Rusholme.

[4] Since the previous redistribution of seats in 1885, they had formed part of the Stretford Division of Lancashire.

[5] The re-established seat comprises the City of Manchester wards of Ardwick, Fallowfield, Hulme, Moss Side, Rusholme and Whalley Range,[6] transferred in approximately equal parts from Manchester Central and the abolished constituency of Manchester Gorton (remaining parts included in the new constituency of Gorton and Denton).