Seven different players scored for United (excluding Jan Bednarek's own goal), equalling the all-time Premier League record of most goalscorers for the same team in a single match, set when Chelsea beat Aston Villa 8–0 in December 2012.

[10] While Manchester United had a full squad available heading into the match, Southampton were missing several players through injury, including Ibrahima Diallo, Michael Obafemi, Oriol Romeu, Mohammed Salisu, Will Smallbone, Nathan Tella, Jannik Vestergaard, Theo Walcott and Kyle Walker-Peters.

Right-back Walker-Peters had not played since Southampton's 1–0 FA Cup fourth round win over Arsenal and was deputised by Kayne Ramsay, as Yan Valery had been loaned to Birmingham City before the transfer deadline the previous day.

[13] Manchester United's only change to their starting line-up saw Mason Greenwood come in for Paul Pogba, while Brandon Williams, who had been a candidate to go out on loan during the transfer window, replaced Axel Tuanzebe on the bench.

[16] In the second minute of the match, Southampton midfielder Alexandre Jankewitz, on his first start for the club, was sent off for a high challenge on Scott McTominay.

[17] Now with a man advantage, Manchester United opened the scoring in the 18th minute, when right-back Aaron Wan-Bissaka met a cross from Luke Shaw at the back post.

[17] At half-time, Manchester United brought on Anthony Martial and Donny van de Beek in place of Cavani and Shaw.

[17] Ché Adams thought he had pulled a goal back for Southampton eight minutes into the second half, only to have it ruled narrowly offside by the video assistant referee.

[26] In August 2022, the result was equalled by Liverpool's 9–0 win over AFC Bournemouth, the fourth match in Premier League history to be won by such a scoreline.