Mandelieu-la-Napoule (French pronunciation: [mɑ̃dəljølanapul]; Occitan: Mandaluec la Napola; locally spelled Mandelieu-La Napoule) is a commune in the Alpes-Maritimes department of the Provence-Alpes-Côte d'Azur region in Southeastern France.

Henry Clews Jr was a painter and sculptor whose work still fills the castle, which is now run as a non-profit arts foundation by his descendants.

The château designed by the Clews has cloister, terrace overlooking the Mediterranean Sea, Gothic dining room, and studio.

Mandelieu-la-Napoule station is served by regional trains (TER Provence-Alpes-Côte d'Azur) towards Fréjus, Cannes, Nice and Les Arcs–Draguignan.

Italian Princess Maria Francesca of Savoy, daughter of the King of Italy Victor Emmanuel III and Queen Elena of Montenegro, lived in Mandelieu and died there on 7 December 2001.