Mandleshwar is a town and nagar panchayat in the Khargone district of the India state of Madhya Pradesh.

It is a "Pavitra nagri" as termed by the government of Madhya Pradesh, as it is an ancient town.

The eighth-century philosopher Maṇḍana Miśra reportedly lived in the town and debated with Aadya Guru Shankarachaarya at the Gupteshwar Mahadev Temple.

The British Raj is memorialized in the Sub-Divisional Magistrate, PWD office, the district jail, fort and the 'ghat'.

Dhawal-kunda and Hathani (islands), Sahastradhara, and Ram kund are other places of historical significance.