Mandritsara is a district in northern Madagascar.

It is a part of Sofia Region and borders the districts of Befandriana-Avaratra in north, Maroantsetra in northeast, Mananara in east, Soanierana Ivongo in southeast, Andilamena in south and Boriziny (Port-Bergé) in west.

The area is 10,512 km2 (4,059 sq mi) and the population was estimated to be 320,647 in 2020.

[1][2] The district is further divided into 22 communes:

This Sofia Region of Madagascar location article is a stub.