Manerbio (Brescian: Manèrbe) is a town and comune in the province of Brescia, in Lombardy, northern Italy.
The name Manerbio derives from Latin Minervium, due to the ancient necropolis found in its territory which was sacred to Minerva, a Roman goddess.
During the Middle Ages, in Manerbio was located a castle which during the conflict between Guelphs and Ghibellines get besieged and destroyed by the Holy Roman Emperor Henry IV (1191) and by the King of Sicily Charles of Anjou (1271).
Due to the conflict between the Duchy of Milan and the Republic of Venice, it get renewed and engaged in sieges several times.
Manerbio began to be a point of reference for the neighbouring town when, due to the Battle of Solferino (1859), arose many rescue facilities which subsequently evolved in a hospital.