Manfredonia (Italian: [maɱfreˈdɔːnja]) is a town and commune of Apulia, Italy, in the province of Foggia, from which it is 35 kilometres (22 miles) northeast by rail.

The modern city of Manfredonia was built by King Manfred between 1256–1263, several kilometers north of the ruins of the ancient Sipontum.

It counts 7 civil parishes (frazioni): Borgo Mezzanone, Riviera Sud (Sciali and Ippocampo), Pastini, Ruggiano, San Salvatore, Siponto and Tomaiuolo.

The Abbey of San Leonardo in Lama Volara, nearer to Foggia, belonging to the Teutonic Order, is of the same date.

Other stations serving the municipal territory are Manfredonia Città (closed), Siponto (in the homonymous village), Frattarolo, Candelaro and Amendola.