[4] The project spans 8 acres and features four office towers, one boutique hotel, one residential building, 225,000 square feet (20,900 m2) of retail space[3] and a 2.5-acre (1 hectare) public plaza.

By the end of 2014, a $680 million platform over train tracks leading into Penn Station between Tenth and Dyer Avenues, atop which the Manhattan West development would be built, was completed.

[4] In September 2021, a $50 million plan to build pedestrian bridges connecting the High Line and Manhattan West was announced by New York Governor Kathy Hochul and Brookfield Properties.

In order to avoid the tracks, the perimeter columns on the south, north, and east sides do not come down to ground level, but are transferred to the core above the building's lobby.

[18] Placed outside One and Two Manhattan West, Charles Ray's sculpture Adam and Eve (2023) consists of two larger-than life figures made of stainless steel blocks.

[36] Installed in the lobby of Two Manhattan West, Christopher Wool's Crosstown Traffic (2023) measures 28ft by 39ft and is both his first mosaic as well as his largest work of art.

[37] Law firm Cravath, Swaine & Moore announced in October 2019 that it would occupy thirteen floors at Two Manhattan West, solidifying its place as the anchor tenant.

[22] Formerly known as Westyard Distribution Center, the building at 450 West 33rd Street was designed by Davis Brody Bond and originally opened in 1969.

[45][46] The 1.8-million-square-foot (170,000 m2), 16-story building[47] originally had a beige precast concrete facade with a sloped base, which was seen as out of place with the architecture of the surrounding neighborhood.

Current tenants include the law firm Skadden Arps, Slate, Meagher, & Flom, LLP, Ernst & Young,[53] McKool Smith,[54] Accenture,[55] W. P. Carey,[56] and Pharo Management.

[58][59] In October 2019, the law firm Cravath, Swaine & Moore signed for space in Two Manhattan West, intending to move its headquarters to the building and occupy 13 floors.

Justin Davidson, in an article about the development's opening for New York, compared Manhattan West favorably to Hudson Yards, writing that the Brookfield development "[...] feels like a corner of New York conceived with actual human beings in mind" while Hudson Yards "[...] has aged from a shiny new space station to a disconsolate one".