Manicoré's origins date back to 1637, with the expedition of Pedro Teixeira, a Portuguese explorer and military man.

[1] The authorities of Grão-Pará sent an escort to the Madeira River in 1716, commanded by João de Barros e Guerra, an experienced captain.

In 1797, the village of Crato was founded, under orders from the Governor of Grão-Pará, with a view to facilitating commercial transactions between Pará, Mato Grosso and Goiás.

From then on, Manicoré began to receive intense migration from the Northeast, who had fled mainly from the Great Drought of 1877-1878 and also attracted by the Rubber Cycle, which took place in Amazonas and in regions of the state of Acre.

According to data from the National Institute of Meteorology (INMET), for the period 1967 to 1990 and from 1993 onwards, the lowest temperature recorded in Manicoré was 9.4 °C, which occurred on May 17, 1968, and the highest reached 39.8 °C on three occasions, the first being on 11 November 1983 and the other two in 1989, on 14 August and 14 September.

Industries: bakeries, potteries, sawmills, carpentry, joinery, ice factory, metalwork, crusher and an asphalt company.