The district covers an area of 159.71 km2 and had a population of 7,165 at the 2020 Census; the official estimate as at mid 2023 was 7,793.

There are 7 villages (desa), listed with their populations according to the official estimates as at mid 2022: Luhutuban (3,288), Tuniwara (865), Buano Hatuputih (359), Tomalehu Barat (1,057), Tomalehu Timur (285), Kelang Asaude (889) and Masawoi (727).

[1] The inhabitants speak the Manipa language, as well as Indonesian and Ambonese Malay.

[2] This island gives its name to the Manipa Strait between Buru and Seram.

Manipa District includes a number of small offshore islands that are very close to its shores.