Bred and raced by Marshall Naify's 505 Farms, she was an exceptionally large filly who stood close to seventeen hands.
Thoroughbred Times reported that she was a "high-strung mare, whose excitability has been her undoing in three disappointing efforts out of state.
She then was shipped to Saratoga Race Course in the New York state where her volatility caused her problems and she ran third to Banshee Breeze in the Alabama Stakes.
In February 2000, the then five-year-old Manistique earned her third Grade I victory in the Santa Maria Handicap while carrying a career-high 125 pounds.
Owner Marshall Naify died on April 19, 2000, and his estate sold Manistique to Aaron and Marie Jones who sent her to serve as a broodmare at Taylor Made Farm near Nicholasville, Kentucky.