Provincial Road 251 (PR 251) is a 55.7-kilometre-long (34.6 mi) east–west highway in the Westman Region of Manitoba.

It serves as the primary road access to the hamlets of Lyleton, Coulter, Waskada, and Goodlands in the very southwest corner of the province.

It heads east through rural areas for several kilometres, passing through the Lyleton community along Railway Avenue before joining Provincial Trunk Highway 83 (PTH 83) in a short concurrency (overlap).

It travels through the centre of town along Park Street, clipping the western edge of downtown at an intersection with Railway Avenue.

After passing through neighbourhoods, the highway makes a sharp right at a junction with PR 452 before leaving Waskada and continuing east through rural farmland.