Provincial Road 253 (PR 253) is a 62.9-kilometre-long (39.1 mi) east–west highway in the Westman and Pembina Valley regions of Manitoba.

It serves as a paved connection to Killarney and Pilot Mound, providing access to Pleasant Valley and Glenora along the way.

PR 253 begins in the Municipality of Killarney-Turtle Mountain at an intersection with PTH 18 7 kilometres (4.3 mi) north of Killarney, heading due east to have its first crossing of the Pembina River before temporarily entering the Cartwright-Roblin Municipality to become concurrent (overlapped) with PR 458.

Entering the Rural Municipality of Prairie Lakes, the highway climbs its way up out of the valley, with PR 458 splitting off to head north shortly thereafter.

[1] Continuing east, PR 253 enters the Rural Municipality of Argyle, having a short concurrency with PTH 5 (Parks Route) just north of Neelin before travelling along the northern side of Rock Lake.