It marks the fourth on-screen joint appearance of Sami Khan and Rabab Hashim after Piya Mann Bhaye, Anaya Tumhari Hui, and Ishqaaway.
Manchali is a story of two cousins, Ambreen and Afsheen, who are polar opposites but promise to stand with each other through thick and thin.
Ambreen is often disliked by her family because of her exuberant and outspoken nature while Afsheen is an innocent and kind-hearted girl who is in love with her next door neighbour, Arham.
To avoid complications between Arham and Afsheen’s relationship, Ambreen is afraid to reciprocate his feelings.
The original soundtrack for Manchali is "Awara Parinda" which is composed by Shuja Haider and the vocals are provided by Ghazal Ali & Nauman Shafi.