Referred to as Technische Hochschule Mannheim in German and previously known as Fachhochschule Mannheim, it offers degree programs at bachelor's and master's level in the fields of engineering, informatics, biotechnology, design, and social affairs.

The Mannheim University of Applied Sciences was founded in 1898 as a private school of engineering for the disciplines of mechanical and electronical engineering, subsidized by the city of Mannheim.

[3] In 1939, it was taken over by the city and named Mannheim School of Engineering.

In 1971, the School of Engineering was officially promoted to the status of a University of Applied Sciences.

In 1995, the City College of Design was integrated into the university as the Faculty of Design, comprising institutes for interactive media, print media, time based media, photography, and design sciences.