Manning Commercial Historic District is a national historic district located at Manning, Clarendon County, South Carolina.

The district encompasses 46 contributing buildings and 1 contributing object in the central business district of Manning, county seat for Clarendon County.

The buildings are characterized by oblique and angled entrances, intriguing decorative cornices and corbeling, and a preponderance of parapeted rooflines give the Manning Commercial Historic District a clear and unmistakable association with the architecture typical of the early-20th century.

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