The Manning Manse is a historic house at 56 Chelmsford Road in North Billerica, Massachusetts.

It has further associations with local and nationally prominent members of the Manning family, and is a significant early example of historic preservation in the United States.

[1] The Manning Manse stands in an isolated setting of northern Billerica, on the south side of Chelmsford Road (Massachusetts Route 129) east of Executive Park Drive.

It is set on about 4 acres (1.6 ha) of land, which is surrounded on three sides by Warren H. Manning State Forest.

It was occupied in the later years of the 18th century by the family of William Manning, a veteran of the American Revolutionary War who wrote the anti-Federalist The Key of Liberty in 1798.