Manocalzati (Irpino: Manëcaozàti) is a town and comune in the province of Avellino, Campania, Southern Italy.

Traces from the Iron Age indicate this town existed in the 8th century BC.

Manocalzati was later a fiefdom of the San Barbato family.

The town retains its original medieval appearance, with narrow streets and palaces with decorated portals from the 18th and 19th centuries.

Within Manocalzati is San Barbato, a small hamlet overlooking the Serinese valley.