Manohisoa is a town and commune in Madagascar.

It belongs to the district of Betafo, which is a part of Vakinankaratra Region.

The population of the commune was estimated to be approximately 15,422 in 2018.

Primary and junior level secondary education are available in town.

The majority 98% of the population of the commune are farmers, while an additional 2% receives their livelihood from raising livestock.