Manokin Historic District is a national historic district at Princess Anne, Somerset County, Maryland, United States, located at the mouth of the Manokin River.

It consists of the Manokin settlement, which forms a unique and visually interesting area of great historical significance on the Lower Eastern Shore.

These structures, Clifton, More and Case It, Almodington, Elmwood, and Homewood are most strongly linked together visually, culturally, and historically.

The vista from the district to the Chesapeake Bay or from the mouth of the Manokin River upstream remains unchanged from the 17th century.

This article about a Registered Historic Place in Somerset County, Maryland is a stub.