After completing his studies in finance and international relations in Cali, Colombia, Cardona decided to further his artistic education abroad.

In addition to his successful acting career, Cardona is also recognized for his philanthropic efforts and advocacy work.

In 1995, at the age of 18, he began his acting career on a popular Colombian Television series called Padres e hijos in which he starred for three years.

A year later he starred in the telenovela ¿Por qué diablos?, portraying a young man who becomes part of a drug organization so he can avenge his friend's death.

In 2002 he signed an exclusive contract with Telemundo and Argos Comunicación, and a year later in 2003 he starred in his first Mexican telenovela, Ladrón de Corazones, where he portrayed Gustavo Velazco, a man who returns to his home town in Mexico after ten years to avenge his father's death and clear his name.

[citation needed] In 2005 he starred in the film La mujer de mi hermano opposite Bárbara Mori and Christian Meier which was released in the United States in 2006.

In 2008, Cardona appeared in El Cartel de los Sapos for Caracol TV where he played a drug dealer.

[6] Cardona appeared in an episode of Tiempo final titled "La entrega" in the second season of the series which also co-starred his girlfriend Katarina Sacht.

Cardona was in the third season of Spain's version of Sin tetas no hay paraíso, which aired on Telecinco.

The short premiered in Colombia in 2009 and was produced by his film production company 11:11 FilmHe starred in Netflix's Who Killed Sara?