Manosque (French pronunciation: [manɔsk]; Provençal Occitan: Manòsca in classical norm or Manosco in Mistralian norm) is the largest town and commune in the Alpes-de-Haute-Provence department in southeastern France.

Manosque is located at the far eastern end of the Luberon near the Durance river.

[citation needed] Commerce thrived in the town in the 13th century leading the population to increase to 10,000 inhabitants.

The population suffered greatly starting in the 18th century due to plagues in 1720 and 1834.

[citation needed] Between 1950 and 1970, the town had a huge increase in population along with other areas south of the Luberon.