In 1836, Charles Henry Manship moved from Maryland to Jackson, Mississippi, where he became a prominent businessman, civic leader, and mayor during the American Civil War.

[4] The house was constructed as a one-story, wood-frame structure in "Gothic Revival" architectural style on a four acre lot.

[3] The house was occupied continuously by members of the Manship family from 1857 until 1975, when it was acquired by the state of Mississippi to serve as a museum.

[4] Between 1976 and 1980, renovation and restoration work on the Manship House was administered by the Mississippi Department of Archives and History.

[4] As of February 2015, the Manship House Museum was closed while undergoing additional restoration and repairs of the building's foundation.