The railway from Mantes-la-Jolie to Cherbourg is an important French 228-kilometre long railway line, that connects Mantes-la-Jolie, a western suburb of Paris, with the northwestern port city Cherbourg via Caen.

[3] The line serves the towns Mantes-la-Jolie, Évreux, Bernay, Lisieux, Caen, and is extended to Cherbourg.

It was electrified with 25 kV AC in June 1996.

A concession for a railway from Mantes to Caen was already granted in 1846, but the first section from Mantes to Lisieux was only opened in July 1855.

[3] The line was known for using the post-World War II, American-built SNCF 141R steam engines as well as turbotrain-type trains from September 1970.