Manuel Antonio de Varona y Loredo (November 25, 1908 in Camagüey, Cuba – October 29, 1992 in Miami, Florida, United States) was a Cuban lawyer and politician.

Varona is 7th Prime Minister of Cuba in 1948–1950, and served as president of the Cuban Senate from 1950 to 1952.

During Varona's exile in Miami, the CIA supported his operational planning for the Bay of Pigs Invasion.

They provided pills laced with botulinum toxin to effect the assassination of Fidel Castro.

A transcript declassified in 2021 of a 1975 Church Committee hearing detailed the covert CIA operation to assassinate Castro: Mr. Breckinridge: Just before the first phase ended, Roselli, through Trafficante, was introduced to another Cuban exile leader in Miami by the name of Anthony Varona.

Varona was the leader of one of the groups that was being supported by the CIA as part of the preparation for the Bay of Pigs.

On one previous occasion Botulinum had been considered for use on cigars that someone had hoped to get to Castro, and eventually that never got off the ground.