Throughout his childhood and adolescence, he lived in Venezuela along with his father, who had been invited by President Joaquín Crespo to undertake public works activities in Caracas.

At 14, Manuel Cabré entered the Academy of Fine Arts of Caracas, where his father taught Sculpture.

[1] In 1912, along with Leoncio Martinez, Rafael Aguin, Cruz Alvarez Garcia, Julian Alonzo, Antonio Edmundo Monsanto and other artists, Cabré founded the Círculo de Bellas Artes, an anti-academic group which rebelled against Antonio Herrera Toro's teaching methods.

[2][3] Enamored with the Venezuelan landscape, he soon moved to the Cerro El Ávila mountains north of Caracas, where he painted in many different shades and from many different angles.

Manuel Cabré was a landscape painter with a proficiency in technique, color and form.