Manuel Márquez Sterling (born Carlos Manuel Agustin Márquez Sterling y Loret de Mola on August 28, 1872 in Lima, Peru – December 9, 1934, Washington, DC, United States) was a Cuban diplomat and interim President of Cuba for 6 hours on January 18, 1934.

After a journalistic career he served in diplomatic service for many years.

He was married to his cousin, Mercedes Márquez Sterling y Ziburo.

He was the uncle of Carlos Márquez Sterling, a figure in Cuban politics whom he adopted as his son.

He tied for 16-17th in the Paris 1900 chess tournament (Emanuel Lasker won) played during the world exhibition.