[1] He was the son of Jose Flores De Abrego and Maria Rodriquez [2][3] They were a prominent family of Bexar, rich in the ranching history of Texas and steeped in the cause of secession from Mexico.

[12] Anticipating the Battle of Gonzales,[13] a meeting would be held late in September 1835 at the Flores Ranch, that would organize a volunteer force of Texas ranchers that would favor the impending revolution.

Manuel and his brother, Salvador Flores, along with Manuel Leal, organized 41 volunteers from ranches southwest of San Antonio,[15] where they reinforced the Texan forces on the Salado Creek, in mid-October,[16] a few days after Juan Seguin[17][18][19] and Plácido Benavides[20] of Victoria had also gathered 70 men to aid Commander Stephen F.

In 1907, Alamo survivor Enrique Esparza stated that Santa Anna called an armistice for three days and he remembers the Flores brothers leaving at that time.

[25] They had entered the Alamo hastily when the Mexican army arrived and now they took the chance to check on the condition of their families, who had been left alone in their homes.

[33] Manuel Flores is credited for taking the lead in the final charge against Santa Anna's army at San Jacinto.

José Maria Rodriquez states in his book Memoirs of Early Texas, that during the final charge, the Texans fired and fell to the ground waiting for a volley from the Mexican camp, but Manuel Flores remained standing and challenged the Texican Army to "get up" and follow his lead, for the Mexicans were running.

[35][Notes 2] In 1838 he established a ranch on the south side of the Guadalupe River near a natural rock waterfalls and directly across from Seguin, Texas.

During March 1842, the citizens of San Antonio sought refuge at Manuel Flores Ranch in the city of Seguin, Texas.

[36] There, a counterattack was planned and Manuel Flores was a member of the party that pursued the army of Ráfael Vásquez.

[39] The Flores ranch in Seguin would again become a base camp when General Adrian Woll attacked San Antonio in September 1842.

Note that Seguin's men at the Alamo were scouts/couriers going in and out, between San Antonio and nearby Gonzales, the rallying point for volunteers.