His family were friends with comedians Wenceslao Fernández Flórez and Enrique Jardiel Poncela, who influenced Vázquez's humor.

He created a lot of characters, for example: Las hermanas Gilda (The Gilda Sisters) (The adventures of two very different sisters), Anacleto, agente secreto (Anacleto, Secret Agent) (A surrealist parody of James Bond), La familia Cebolleta (The Scallion Family) or El tío Vázquez (Uncle Vázquez) (A self- parody) When Editorial Bruguera disappeared he also joined in adult magazines such as El Papus or Makoki with the alias Sappo.

The character of the rooftop debtor in the cartoon 13, Rue del Percebe was based on Vázquez by Francisco Ibáñez.

Ibáñez considered Vázquez the most agile cartoonist, the funniest in Spanish comics.

[1] There is a 2010 biopic film based on his life called El gran Vázquez directed by Óscar Aibar and starring Santiago Segura.