Manuel de Mederos (1539–1613) was a Portuguese explorer and settler who was active in the Spanish conquest of Mexico.
He was part of the expedition of Luis Carvajal y de la Cueva during the conquest of northern Mexico and was one of the original founders of the city of Saltillo, Coahuila, on July 25, 1577.
Captain de Mederos's hacienda was located south of the Villa of Saltillo, next to the properties of Alberto del Canto and Juan Alonso, close to Buenavista.
On April 22, 1613, he donated land in Santa Catarina to his goddaughter Andrea Rodríguez, wife of Blas Pérez.
The Universidad Autónoma de Nuevo León (UANL) has a campus named after him, and there is a Capitán Mederos Avenue in the city of Monterrey.